WebbConclusions: The therapeutic range of phenytoin is defined on an individual basis. Some patients, especially those with infrequent, primary tonic-clonic seizures, may be … WebbThe majority of serum phenytoin concentrations were in the therapeutic range. Estimating weight in children for the 20 mg/kg intravenous loading dose of phenytoin is often …
Phenytoin: A Guide to Therapeutic Drug Monitoring - SAGE Journals
Webb11 jan. 2009 · The therapeutic range for serum phenytoin levels is 10 to 20 mg/dL, but achieving and maintaining a level in this range can be challenging. Several factors—including the patient’s albumin level and other medications—can make the phenytoin level quickly slip out of range, resulting in breakthrough seizures or toxicity. WebbPhenytoin is an effective and widely used antiepileptic drug. On the other hand, it has a narrow therapeutic range and many side effects such as skin rash, hepatitis, cardiac arrhythmia, hypotension, and even seizures. An oral loading dose of phenytoin is now well established, as is its effectiveness, and seems to be safer and cheaper(1,2). churches in malvern worcestershire
PNYG - Overview: Phenytoin, Total and Phenobarbital Group, Serum
WebbOrally administered phenytoin is used chronically to provide prophylaxis against tonic-clonic or partial seizures. Phenytoin is a type 1B antiarrhythmic and is also used in the treatment of trigeminal neuralgia. Table 10-1 International Classification of Epileptic Seizures with Treatment Recommendation View Table Download (.pdf) Webb12 apr. 2024 · 1. Pregnancy should be avoided while taking phenytoin. 2. The client may stop the medication if it is causing severe gastrointestinal effects. 3. There is the potential of decreased effectiveness of birth control pills while taking phenytoin. 4. There is the increased risk of thrombophlebitis while taking phenytoin and birth control pills ... Webb25 juni 2013 · Phenytoin is a commonly prescribed anticonvulsant used to treat most types of seizure disorders and status epilepticus, ... dose-related toxicity that is an important issue in emergency medicine. 1 Its wide pharmacokinetic variability and narrow therapeutic range often leads to toxicity which may have varied manifestations. development editing academic