WebDec 11, 2024 · In this review article, we present the current knowledge on PTPN13, a class I non-receptor protein tyrosine phosphatase identified in 1994. We focus particularly on its role in cancer, where PTPN13 acts as an oncogenic protein and also a tumor suppressor. To try to understand these apparent contradictory functions, we discuss PTPN13 implication in … WebThe PTPN13 gene is located on chromosome 4q21, a region frequently deleted in ovarian, lung and liver cancer . In addition, PTPN13 mRNA expression is an independent prognostic marker of increased overall survival in breast cancer , in hepatocellular carcinoma , lung cancer and in high grade serous ovarian cancer .
PTPN13 protein expression summary - The Human Protein Atlas
WebThe protein encoded by PTPN13 has a predicted amino acid length of 2485, a mass of 276.9 kDa, and a cytoplasmic and nuclear subcellular localization. There are currently 4 reported isoforms. PTPN13 may also be known by the following names: FAP-1, protein-tyrosine phosphatase PTPL1, hPTPE1, fas-associated protein-tyrosine phosphatase 1, … WebBreast adenocarcinoma is the most common of all cancers that occur in women. According to the United States of America survey, more than 282,000 breast cancer patients are registered each year; most of them are women. Detection of cancer at its early linda howard go team series
PTPN13 acts as a tumor suppressor in clear cell renal cell
WebJan 23, 2016 · Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality and carries a dismal prognosis. The present study aimed to identify the tumour-suppressive role and clinical implications of PTPN13 in HCC progression. We tested the effects of PTPN13 expression in proliferation, invasion, epithelial–mesenchymal … WebGene "Gene description" Evidence A1CF "APOBEC1 complementation factor" "Evidence at protein level" A4GALT "Alpha 1,4-galactosyltransferase (P blood group)" "Evidence at protein le WebNov 13, 2024 · 本研究中报道了11例alk阳性局部晚期nsclc接受新辅助克唑替尼治疗。 所有患者治疗后均观察到肿瘤灶缩小,2例(18.2%)患者取得病理完全缓解。 此外,5例复发的患者,在复发后接受克唑替尼一线治疗,观察到较好的疗效,提示新辅助克唑替尼治疗后仍可以在后续复发一线克唑替尼治疗中取得较好疗效。 linda howard latest book