WebJun 15, 2007 · Cell cycle arrest in response to DNA damage involves protein stabilization and consequent upregulation of p53, which induces transcription of cyclin-dependent kinase inhibitor p21 (CDKN1A). We now show that p21 acts as a negative regulator of the cellular levels of p53. p21 knockdown by short hairpi … WebJun 30, 2024 · PIM kinases are novel negative regulators of LKB1 that affect AMPK activity in an LKB1-dependent fashion. The impairment of cell proliferation and tumor growth in cells lacking both LKB1 and PIMs indicates that these kinases possess a shared signaling role in the context of cancer.
PIM Kinases Are Essential for Chronic Lymphocytic Leukemia Cell ...
WebJan 1, 2024 · PIM1 is up-regulated in renal IRI and attenuates ischemic injury and hypoxia-induced tubular cell injury. ... including CDKN1A/B, Bad, DRP1, EIF4B, RUNX, and so on [36], [37]. In our transcriptome sequencing, we found that the MAPK pathway, which mediates death and survival of various cells, was significantly enriched after renal IRI with PIM1 ... WebFeb 9, 2010 · Further analysis revealed that the open reading frame of PIM1 encoded for a protein of 313aa extending over 6 exons, with highest homology to serine/threonine … samsung tv with voice command
PIM kinase inhibition: co-targeted therapeutic approaches …
WebJun 25, 1999 · The pim-1 oncogene encodes a serine/threonine kinase (Pim-1) involved in the transduction of cytokine-triggered mitogenic signals. Pim-1 is unique in that it closely … WebMay 19, 2016 · Our results suggested a majority of genes were suppressed by miR-124a expression, including cell cycle regulators CDC25A, CDKN1A, CDK2, CDK4, and E2F1; apoptosis APAF1 and Bcl2; transcription factors Ets2, Fos, Jun, and Myc; signaling molecules IL-8, tumor necrosis factor, and TEK; and cell migration factors such as MMP1, … WebMar 21, 2024 · This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. samsung tv with vizio soundbar