Chloroethylnitrosoureas
WebJun 1, 1989 · The results underline that the therapeutic activity of chloroethylnitrosoureas is mainly attributable to their cross-linking potential while induction of DNA single-strand breaks plays a decisive role for mutagenicity and carcinogenicity but appears not to be relevant for antineoplastic effectiveness. WebMar 23, 2015 · Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine DNA base pair. However, the formation of dG-dC crosslinks can be prevented by O6-alkylguanine-DNA alkyl …
Chloroethylnitrosoureas
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Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebChloroethylnitrosoureas (CENUs) are an important family of chemotherapies in clinical treatment of cancers, which exert antitumor activity by inducing the formation of DNA interstrand crosslinks (dG-dC ICLs). However, the drug resistance mediated by O6-alkylguanine-DNA alkyltransferase (A …
WebInvestigations on the Effect of O6-Benzylguanine on the Formation of dG-dC Interstrand Cross-Links Induced by Chloroethylnitrosoureas in Human Glioma Cells Using Stable Isotope Dilution High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. Chemical Research in Toxicology, 27(7), 1253–1262. … WebChloroethylnitrosoureas are anticancer agents that undergo chemical reactions in vitro and in vivo to form active alkylating agents. The rate at which lipophilic chloroethylnitrosourease decompose in serum is faster than in aqueous solution and comparable to in vivo clearance rates.
WebMar 23, 2015 · Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine DNA base pair. However, the formation of dG-dC crosslinks can be prevented by O6-alkylguanine-DNA alkyltransferase (AGT), ultimately leading to drug … WebSep 1, 1987 · Abstract. DNA damage caused by methazolastone [an analogue of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide which does not require metabolic activation] was investigated in L-1210 leukemia which is sensitive to this drug and in a L-1210 subline [L-1210/N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU)] which is resistant to both …
WebCompared to 9L cells, 9L-2 cells were very resistant to the cytotoxic effects of 1,3-bis (2-chloroethyl)-1-nitrosourea, and to 2- [3- (2-chloroethyl)-3-nitrosoureido]-D-deoxyglucopyranose. The sensitivity of 9L-7 and 9L-8 cell lines to these drugs was intermediate between 9L and 9L-2.
WebJul 21, 2014 · Chloroethylnitrosoureas (CENUs) are bifunctional alkylating agents widely used for the clinical treatment of cancer. They exert anticancer activity by inducing DNA interstrand cross-links (ICLs) within GC base pairs to form dG-dC cross-links. This lesion inhibits DNA double strand separation during replication and transcription and results in ... heart touching farewell quotes for friendsWebChloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert their antitumor activity through inducing the formation of dG-dC interstrand crosslinks (ICLs) within DNA double strand. However, the complex process of tumor biology enables tumor cells to escape the killing t … heart touching christian songsWebThe objective of this work was the molecular modelling by bio-isostery of 2-chloroethylnitrosoureas CENU into 2-chloroethylnitrososulfamides CENS derived from Carmustine. We evaluated the pharmacod... moussaka slow cooker recipesWebApr 1, 2024 · Chloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert their antitumor activity through inducing the formation of dG-dC … moussaka recipe with yogurt and egg toppingWebMar 1, 1986 · The chloroethylnitrosoureas (CENUs) represent a class of bifunctional alkylating agents that have proved clinically useful for cancer chemotherapy. The group includes carmustine (BCNU), lomustine ... heart touching friendship quotesWebAbstract. Chloroethylating nitrosoureas (CNU), such as lomustine, nimustine, semustine, carmustine and fotemustine are used for the treatment of malignant gliomas, brain … moussaka rick stein recipeWebChloroethylnitrosoureas (BCNU, CCNU, meCCNU, fotemustine, ACNU, clomesone) and related methylating agents (methyltriazenes: DTIC, temozolomide; methylnitrosoureas: … moussaka torte schuhbeck